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Cardiology

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What is the indication for low-dose aspirin for primary prevention?

What EKG findings do you expect to see in STEMI?

 

What is Wellen’s Pattern or Syndrome?

  • Deep T-wave inversions in multiple precordial leads eg V1-V4 in a patient presenting with ischemic chest pain can suggest high-grade LAD stenosis

  • Sample EKG: https://www.jetem.org/wellens/

How might RV infarction present? What is a unique aspect of treatment of RV infarction?

 

ICDs are indicated post-MI if which criteria are met?

  • >40 days since MI or >3 months since PCI/CABG 

                                  And

 

How long do you need dual anti-platelet therapy (DAPT) for a BMS vs DES?

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What signs/symptoms have the highest likelihood ratio for HF? 

  • PND and S3

 

What are the NYHA functional classes?

  • Class 1. No limitation in physical activity

  • Class 2. Slight limitation of physical activity

  • Class 3. Marked limitation of physical activity

  • Class 4. Unable to carry on any physical activity without symptoms

 

What are the AHA stages of heart failure?

  • Stage A: at risk for HF but without structural heart changes

  • Stage B: structural heart disease but without heart failure symptoms

  • Stage C: structural heart disease with current or prior heart failure symptoms

  • Stage D: refractory heart failure requiring advanced intervention 

 

What degree of BNP level elevation is very suggestive of HF? Less than what level is suggestive against HF? 

  • Generally, >400 very suggestive; <100 suggestive against

  • Falsely low BNP in obesity

  • Unreliable BNP in ESRD and patients on entresto

 

Indication and benefit for typical HFrEF medications?

  • ACE/ARB: all stages; reduces mortality

  • Entresto: class II-IV, EF <40%; reduces mortality more so than ACEI/ARBs alone

  • Hydralazine+nitrates: class III-IV in addition to standard therapy and in those who cannot tolerate ACEi/ARBs; reduces mortality in African-American patients with HFrEF

  • Beta blockers (specifically Metoprolol succinate, carvedilol, and bisoprolol): all classes, reduces mortality

  • Aldosterone antagonists: class III-IV or class II PLUS EF < 35%; reduces mortality

  • Digoxin: may improve refractory symptoms; decreases hospitalizations, no mortality benefit

  • Diuretics: volume overload; decreases symptoms and hospitalizations

  • SGLT-2 inhibitors: reduces mortality in HFrEF and reduces hospitalizations in HFpEF (EMPEROR preserved trial)

  • Ivabradine: EF <35% with HR >70 despite max BB

  • ICD: class II-III with EF <35%, class I with EF <30; improves survival (note that class IV is provided no mortality benefit)

  • https://www.ahajournals.org/doi/10.1161/CIR.0000000000001063

  • https://twitter.com/Drroxmehran/status/1431253161856184325

 

Indication and benefit for typical HFpEF medications?

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How might a patient in cardiogenic shock present?

 

How would you manage a patient with cardiogenic shock?

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What are the classes of pulmonary HTN?

 

For new pHTN, what tests should you order?

  • Liver chemistries, HIV, thyroid function, ANA, anticentromere antibody

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What are possible causes of pericarditis?

  • Viral infections (Coxsackie), uremia, autoimmune, bacterial, trauma, post-MI (Dressler’s syndrome)

 

What is the treatment of pericarditis?

 

What are typical EKG findings in pericarditis?

  • Diffuse concave ST elevation

  • PR depression

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What are the exam findings with effusions?

  • Tachycardia, muffled heart sounds, elevated JVP, pulsus paradoxus

  • Pulsus paradoxus - an exaggerated drop in systemic blood pressure of greater than 10 mmHg during inspiration

 

What is the unique EKG finding with effusions?

  • Electrical alternans

 

Management of pericardial effusions?

  • Pericardiocentesis or pericardial window

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What is the most common EKG finding in PE?

 

What are the EKG changes that may be seen with hyperkalemia?

  • Peaked T waves, PR prolongation, widening QRS, p wave flattening

 

What does a J-wave or Osborne wave indicate?

  • Hypothermia or hypocalcemia

 

What medications commonly prolong the QT interval?

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What are the types of heart block that require a pacemaker? 

  • Mobitz type 2 second degree and third-degree/complete

 

Which types of heart block is atropine best indicated for?

  • 1st degree and 2nd degree mobitz type 1

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What are some causes of sinus bradycardia (HR <50)? 

  • Hypoxia, ischemic event, infection, meds (AV-nodal blockers/opioids/sedatives/acetylcholinesterase inhibitors), hypothermia, hypothyroidism (myxedema coma), OSA, hyperkalemia, post cardiac surgery, athletes, age-related myocardial fibrosis

 

When do you treat sinus bradycardia? 

  • Only if a patient is symptomatic (lightheaded/dizzy, fatigue, syncope, dyspnea, chest pain, confusion) or hemodynamically unstable

 

Why can bradycardia be dangerous? 

  • Decreased heart rate will lead to decreased cardiac output if stroke volume cannot appropriately compensate (CO = HR x SV) → cardiogenic shock

 

What are the first-line medications? 

  • Atropine 0.5mg q3-5 minutes, maximum 3 mg → if unstable or not working, dopamine gtt or epi → Transcutaneous/venous pacing (transfer to CCU). Also, consider giving calcium as many bradycardias are calcium-responsive

  • https://emcrit.org/ibcc/bradycardia/#calcium

 

What are the absolute indications for a pacemaker for bradycardia? 

  • Class I = Documented symptomatic sinus bradycardia including frequent sinus pauses;

  • Class II = Sinus bradycardia with heart rate less than 40, but no clear association between the symptoms and bradycardia or Minimally symptomatic patients with chronic heart rate less than 40 while awake

  • https://www.ncbi.nlm.nih.gov/books/NBK507823/

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What are long standing risk factors for afib? 

  • Age, HTN, CAD, T2DM, smoking, obesity, OSA, moderate to heavy alcohol consumption 

 

What testing should patients undergo? 

  • Check TSH 

  • Echo to look for valvular or structural disease and assess extent of LA dysfunction 

  • Sleep study if patient is at increased risk of OSA

 

Afib RVR management:

https://twitter.com/thame/status/1064576827245645825/photo/1

  • Stable → IV Metoprolol vs IV Diltiazem

  • Unstable → Cardiovert

  • Borderline

    • IVF trial

    • Metoprolol or Esmolol

    • Digoxin

    • Amiodarone

  • EF <40%, avoid diltiazem 

  • Contraindications for B blockers - severe COPD, acute asthma exacerbation, hypotension, decompensated CHF (cardiogenic shock)

 

Is rate control vs rhythm control preferred in patients with Afib:

 

When is anticoagulation indicated?

  • If the duration of afib <48 hours, low risk for thrombus formation and stroke. Can cardiovert without anticoagulation. 

  • If the duration of afib is unknown or >48 hours, anticoagulation is needed 3 weeks before cardioversion OR TEE can be performed to rule out thrombus followed by cardioversion

  • Regardless of the duration of afib, all patients should receive 4 weeks of anticoagulation following cardioversion due to increased risk of thombro-embolic events after sinus rhythm is restored

 

What are the indications for anticoagulation in afib?

 

What are indications (ABCD) for decreased dosing of apixaban in afib? 

Which leads typically best demonstrate flutter waves? 

  • Inferior leads 

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What is SVT?

  • Abnormally rapid HR, typically narrow complex (not always)

 

How do you manage SVT?

  • Trial vagal maneuvers (blow into a straw)

  • Push adenosine → 6 mg, then 12 mg

  • Tell patient they will have impending sensation of doom, have pads on, have continuous EKG on

  • Consider cardioversion if refractory

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Easily addressed etiology of VTach in hospital?

  • Electrolyte abnormalities

 

Etiologies of PEA?

  • Hs and Ts

    • Hypovolemia

    • Hypoxia

    • Hydrogen ion (acidosis)

    • Hypo/hyperkalemia

    • Hypothermia

    • Tension pneumothorax

    • Trauma

    • Tamponade

    • Thrombosis, pulmonary

    • Thrombosis, coronary

​​https://www.ncbi.nlm.nih.gov/books/NBK513349/

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What are the three main indications for AVR? 

  • Symptoms, EF <50% in asymptomatic patients, undergoing concomitant cardiac surgery

 

What are the indications for open surgery > TAVR?

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What is first line therapy for symptomatic mitral stenosis?

  • Percutaneous balloon mitral commissurotomy

 

Presentation of acute mitral regurgitation?

  • Dyspnea, pulmonary edema, even cardiogenic shock

 

Treatment of acute mitral regurgitation?

  • Nitroprusside, balloon pump, surgical correction 

 

Indications for surgical repair in chronic mitral regurgitation?

  • Symptomatic

  • Asymptomatic with EF <60% and/or LV ESD >40 mm

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What is the medical management of dissections?

  • Tight blood pressure control to 100-120 systolic, can use nitroprusside or beta blockers

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