Lankenau Pearls
Cardiology
+
-
What is the indication for low-dose aspirin for primary prevention?
-
Adults 40-59 with a 10-year ASCVD risk of 10% or higher with no increased risk for bleeding
What EKG findings do you expect to see in STEMI?
-
ST elevation of >/=1 mm in >/=2 contiguous limb or chest leads
-
New LBBB also considered an equivalent
-
Posterior MI will show tall R waves and ST depressions in V1-V4
What is Wellen’s Pattern or Syndrome?
-
Deep T-wave inversions in multiple precordial leads eg V1-V4 in a patient presenting with ischemic chest pain can suggest high-grade LAD stenosis
-
Sample EKG: https://www.jetem.org/wellens/
How might RV infarction present? What is a unique aspect of treatment of RV infarction?
-
Hypotension or development of hypotension after nitro/morphine administration
-
IV fluids
-
Will have ST changes in V1, II, III, aVF
ICDs are indicated post-MI if which criteria are met?
-
>40 days since MI or >3 months since PCI/CABG
And
-
EF <35% and NYHA class II or III, or EF <30% and class I
-
https://www.ahajournals.org/doi/full/10.1161/CIRCEP.117.005194
How long do you need dual anti-platelet therapy (DAPT) for a BMS vs DES?
-
BMS - at least 1 month of DAPT; DES - at least 1 year of DAPT
-
(We also see a lot of variation in provider preference in terms of length)
+
-
What signs/symptoms have the highest likelihood ratio for HF?
-
PND and S3
What are the NYHA functional classes?
-
Class 1. No limitation in physical activity
-
Class 2. Slight limitation of physical activity
-
Class 3. Marked limitation of physical activity
-
Class 4. Unable to carry on any physical activity without symptoms
What are the AHA stages of heart failure?
-
Stage A: at risk for HF but without structural heart changes
-
Stage B: structural heart disease but without heart failure symptoms
-
Stage C: structural heart disease with current or prior heart failure symptoms
-
Stage D: refractory heart failure requiring advanced intervention
What degree of BNP level elevation is very suggestive of HF? Less than what level is suggestive against HF?
-
Generally, >400 very suggestive; <100 suggestive against
-
Falsely low BNP in obesity
-
Unreliable BNP in ESRD and patients on entresto
Indication and benefit for typical HFrEF medications?
-
ACE/ARB: all stages; reduces mortality
-
Entresto: class II-IV, EF <40%; reduces mortality more so than ACEI/ARBs alone
-
Hydralazine+nitrates: class III-IV in addition to standard therapy and in those who cannot tolerate ACEi/ARBs; reduces mortality in African-American patients with HFrEF
-
Beta blockers (specifically Metoprolol succinate, carvedilol, and bisoprolol): all classes, reduces mortality
-
Aldosterone antagonists: class III-IV or class II PLUS EF < 35%; reduces mortality
-
Digoxin: may improve refractory symptoms; decreases hospitalizations, no mortality benefit
-
Diuretics: volume overload; decreases symptoms and hospitalizations
-
SGLT-2 inhibitors: reduces mortality in HFrEF and reduces hospitalizations in HFpEF (EMPEROR preserved trial)
-
Ivabradine: EF <35% with HR >70 despite max BB
-
ICD: class II-III with EF <35%, class I with EF <30; improves survival (note that class IV is provided no mortality benefit)
-
https://www.ahajournals.org/doi/10.1161/CIR.0000000000001063
Indication and benefit for typical HFpEF medications?
-
SGLT2-inhibitors reduce hospitalizations but do not clearly reduce mortality
-
Empagliflozin in Heart Failure with a Preserved Ejection Fraction - PubMed (nih.gov) showed reduced hospitalizations (9% vs 12%) but no difference in mortality
-
-
Spironolactone reduces hospitalizations but not mortality
-
TOPCAT (Spironolactone for heart failure with preserved ejection fraction - PubMed (nih.gov)) showed reduced hospitalizations (12% vs 14%) but no difference in mortality
+
-
How might a patient in cardiogenic shock present?
-
Extremities may be cool, may be confused, may have nonspecific symptoms like nausea/indigestion
-
Evaluate with lactate, LFTs, MVO2 (if central access is in place)
-
MvO2 can be used to calculate CO/CI via Fick principle: http://www.josephsunny.com/medsoft/cardiology.html
How would you manage a patient with cardiogenic shock?
-
Typically requires ICU; initiation of inotropes ((dobutamine, milrinone), consideration of balloon pump, and ECMO
-
Diuresis as able despite hypotension
-
https://www.ahajournals.org/doi/full/10.1161/JAHA.119.011991
-
What are the classes of pulmonary HTN?
-
Group 1: pulmonary arterial hypertension (idiopathic, drugs, HIV, systemic sclerosis)
-
Group 2: secondary to left heart disease
-
Group 3: secondary to lung diseases (COPD, ILD, OSA/OHS)
-
Group 4: chronic thromboembolic pulmonary hypertension (CTEPH)
-
Group 5: multifactorial (primarily sarcoidosis)
-
https://phassociation.org/types-pulmonary-hypertension-groups/
-
pHTN: https://twitter.com/fritsfranssen/status/1471752028950958080
For new pHTN, what tests should you order?
-
Liver chemistries, HIV, thyroid function, ANA, anticentromere antibody
+
+
-
What are possible causes of pericarditis?
-
Viral infections (Coxsackie), uremia, autoimmune, bacterial, trauma, post-MI (Dressler’s syndrome)
What is the treatment of pericarditis?
-
Treat the underlying disease if possible
-
ASA or NSAIDs q8 hrs x 1-2 weeks, colchicine 0.5 mg x 3 months
-
Colchicine has been shown to reduce recurrence of pericarditis
-
Randomized, double-blind study showed that colchicine reduced incessant or recurrent pericarditis compared to placebo (16.7% vs 37.5%)
-
A randomized trial of colchicine for acute pericarditis - PubMed (nih.gov)
-
-
Steroids given for recurrent, incessant pericarditis or autoimmune related
What are typical EKG findings in pericarditis?
-
Diffuse concave ST elevation
-
PR depression
+
-
What are the exam findings with effusions?
-
Tachycardia, muffled heart sounds, elevated JVP, pulsus paradoxus
-
Pulsus paradoxus - an exaggerated drop in systemic blood pressure of greater than 10 mmHg during inspiration
What is the unique EKG finding with effusions?
-
Electrical alternans
Management of pericardial effusions?
-
Pericardiocentesis or pericardial window
-
+
What is the most common EKG finding in PE?
-
Sinus tachycardia
-
S1Q3T3 is commonly associated, but not as commonly seen as sinus tachycardia
-
Indicative of right-heart strain of any cause including PE, so is neither sensitive nor specific for PE
-
What are the EKG changes that may be seen with hyperkalemia?
-
Peaked T waves, PR prolongation, widening QRS, p wave flattening
What does a J-wave or Osborne wave indicate?
-
Hypothermia or hypocalcemia
What medications commonly prolong the QT interval?
-
Antibiotics like fluoroquinolones and macrolides
-
Antipsychotics
-
Antiemetics
-
Prokinetics
-
Electrolyte abnormalities
-
+
What are the types of heart block that require a pacemaker?
-
Mobitz type 2 second degree and third-degree/complete
Which types of heart block is atropine best indicated for?
-
1st degree and 2nd degree mobitz type 1
-
+
What are some causes of sinus bradycardia (HR <50)?
-
Hypoxia, ischemic event, infection, meds (AV-nodal blockers/opioids/sedatives/acetylcholinesterase inhibitors), hypothermia, hypothyroidism (myxedema coma), OSA, hyperkalemia, post cardiac surgery, athletes, age-related myocardial fibrosis
When do you treat sinus bradycardia?
-
Only if a patient is symptomatic (lightheaded/dizzy, fatigue, syncope, dyspnea, chest pain, confusion) or hemodynamically unstable
Why can bradycardia be dangerous?
-
Decreased heart rate will lead to decreased cardiac output if stroke volume cannot appropriately compensate (CO = HR x SV) → cardiogenic shock
What are the first-line medications?
-
Atropine 0.5mg q3-5 minutes, maximum 3 mg → if unstable or not working, dopamine gtt or epi → Transcutaneous/venous pacing (transfer to CCU). Also, consider giving calcium as many bradycardias are calcium-responsive
What are the absolute indications for a pacemaker for bradycardia?
-
Class I = Documented symptomatic sinus bradycardia including frequent sinus pauses;
-
Class II = Sinus bradycardia with heart rate less than 40, but no clear association between the symptoms and bradycardia or Minimally symptomatic patients with chronic heart rate less than 40 while awake
-
+
What are long standing risk factors for afib?
-
Age, HTN, CAD, T2DM, smoking, obesity, OSA, moderate to heavy alcohol consumption
What testing should patients undergo?
-
Check TSH
-
Echo to look for valvular or structural disease and assess extent of LA dysfunction
-
Sleep study if patient is at increased risk of OSA
Afib RVR management:
https://twitter.com/thame/status/1064576827245645825/photo/1
-
Stable → IV Metoprolol vs IV Diltiazem
-
Unstable → Cardiovert
-
Borderline
-
IVF trial
-
Metoprolol or Esmolol
-
Digoxin
-
Amiodarone
-
-
EF <40%, avoid diltiazem
-
Contraindications for B blockers - severe COPD, acute asthma exacerbation, hypotension, decompensated CHF (cardiogenic shock)
Is rate control vs rhythm control preferred in patients with Afib:
-
In patients with atrial fibrillation, rate plus rhythm control offers superior symptom management (improved cardiovascular, stroke, HF and mortality outcomes) compared with rate control alone (EAST-AFNET 4 trial) (https://www.ahajournals.org/doi/full/10.1161/JAHA.121.024214).
When is anticoagulation indicated?
-
If the duration of afib <48 hours, low risk for thrombus formation and stroke. Can cardiovert without anticoagulation.
-
If the duration of afib is unknown or >48 hours, anticoagulation is needed 3 weeks before cardioversion OR TEE can be performed to rule out thrombus followed by cardioversion
-
Regardless of the duration of afib, all patients should receive 4 weeks of anticoagulation following cardioversion due to increased risk of thombro-embolic events after sinus rhythm is restored
What are the indications for anticoagulation in afib?
-
CHADS2-VASC >2 in men or >3 in women
-
Valvular afib (severe mitral stenosis or mechanical valve) → Warfarin
-
Non valvular afib → DOAC
-
Patients with afib and recent PCI → DOAC and clopidogrel or ticagrelor (double therapy)
-
AC in Afib: https://www.aerjournal.com/articles/anticoagulation-atrial-fibrillation-current-concepts
What are indications (ABCD) for decreased dosing of apixaban in afib?
-
Age ≥ 80 years, Body Weight ≤ 60 kg, Creatinine ≥ 1.5 mg/dL and DOUBLE of these factors (aka ≥ 2) then decrease dose from 5 mg bid to 2.5 mg bid
-
https://twitter.com/theABofPharmaC/status/1441520670282706948
Which leads typically best demonstrate flutter waves?
-
Inferior leads
-
+
What is SVT?
-
Abnormally rapid HR, typically narrow complex (not always)
How do you manage SVT?
-
Trial vagal maneuvers (blow into a straw)
-
Push adenosine → 6 mg, then 12 mg
-
Tell patient they will have impending sensation of doom, have pads on, have continuous EKG on
-
Consider cardioversion if refractory
-
+
Easily addressed etiology of VTach in hospital?
-
Electrolyte abnormalities
Etiologies of PEA?
-
Hs and Ts
-
Hypovolemia
-
Hypoxia
-
Hydrogen ion (acidosis)
-
Hypo/hyperkalemia
-
Hypothermia
-
Tension pneumothorax
-
Trauma
-
Tamponade
-
Thrombosis, pulmonary
-
Thrombosis, coronary
-
-
+
What are the three main indications for AVR?
-
Symptoms, EF <50% in asymptomatic patients, undergoing concomitant cardiac surgery
What are the indications for open surgery > TAVR?
-
TAVR typically preferred in those high risk for surgical procedure with severe AS and symptoms although now becoming more popular in those at intermediate risk
-
+
What is first line therapy for symptomatic mitral stenosis?
-
Percutaneous balloon mitral commissurotomy
Presentation of acute mitral regurgitation?
-
Dyspnea, pulmonary edema, even cardiogenic shock
Treatment of acute mitral regurgitation?
-
Nitroprusside, balloon pump, surgical correction
Indications for surgical repair in chronic mitral regurgitation?
-
Symptomatic
-
Asymptomatic with EF <60% and/or LV ESD >40 mm
-
+
What is the medical management of dissections?
-
Tight blood pressure control to 100-120 systolic, can use nitroprusside or beta blockers